Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3754304..3754806 Replicon chromosome
Accession NZ_CP053371
Organism Proteus terrae subsp. cibarius strain G32

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HND96_RS17395 Protein ID WP_075671248.1
Coordinates 3754552..3754806 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HND96_RS17390 Protein ID WP_072068851.1
Coordinates 3754304..3754555 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HND96_RS17365 3749895..3750671 + 777 WP_006534565.1 phosphate ABC transporter ATP-binding protein PstB -
HND96_RS17370 3750686..3751420 + 735 WP_075671254.1 phosphate signaling complex protein PhoU -
HND96_RS17375 3751636..3752475 + 840 WP_036933789.1 ABC transporter substrate-binding protein -
HND96_RS17380 3752582..3753319 + 738 WP_075671252.1 amino acid ABC transporter permease -
HND96_RS17385 3753321..3754073 + 753 WP_075671250.1 amino acid ABC transporter permease -
HND96_RS17390 3754304..3754555 + 252 WP_072068851.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HND96_RS17395 3754552..3754806 + 255 WP_075671248.1 Txe/YoeB family addiction module toxin Toxin
HND96_RS17400 3754963..3756321 + 1359 WP_075671246.1 NCS2 family permease -
HND96_RS17405 3756402..3756713 + 312 WP_098941657.1 monooxygenase -
HND96_RS17410 3756763..3757311 - 549 WP_159363623.1 GNAT family N-acetyltransferase -
HND96_RS17415 3757314..3758786 - 1473 WP_075671240.1 glycosyltransferase family 39 protein -
HND96_RS17420 3758975..3759472 + 498 WP_159363624.1 Der GTPase-activating protein YihI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10170.78 Da        Isoelectric Point: 9.9411

>T156714 WP_075671248.1 NZ_CP053371:3754552-3754806 [Proteus terrae subsp. cibarius]
MKLIFSEQSWSDYLYWQQIDKKIIKRINELIKDIKRTPFSGIGKPEPLKHNLAGFWSRRITDEHRLIYRITDSAIEIASC
RYHY

Download         Length: 255 bp

>T156714 NZ_CP069069:3566226-3566570 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9463.77 Da        Isoelectric Point: 4.4354

>AT156714 WP_072068851.1 NZ_CP053371:3754304-3754555 [Proteus terrae subsp. cibarius]
MKTINYTEARQNLTSIMNETIDDRVPIMITRQKGIPCVLLSLDEYQALEETAYLLRSPANARHLLDSIDELNQGKGIEKD
ITE

Download         Length: 252 bp

>AT156714 NZ_CP069069:3566567-3566896 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References