Detailed information of TA system TA156669

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2641946..2642463
• Replicon: chromosome
• Accession: NZ_CP053356
• Organism: Staphylococcus aureus strain 14507

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: HA034_RS13275
• Protein ID: WP_000113265.1
• Coordinates: 2642197..2642463 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: HA034_RS13270
• Protein ID: WP_000584499.1
• Coordinates: 2641946..2642197 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA034_RS13240	2637644..2638363	+	720	WP_000479576.1	amino acid ABC transporter permease	-
HA034_RS13245	2638360..2639091	+	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
HA034_RS13250	2639188..2640438	-	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
HA034_RS13255	2640693..2641055	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
HA034_RS13260	2641074..2641673	+	600	WP_000162810.1	DsbA family protein	-
HA034_RS13265	2641680..2641781	+	102	Protein_2546	hypothetical protein	-
HA034_RS13270	2641946..2642197	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HA034_RS13275	2642197..2642463	+	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
HA034_RS13280	2642498..2642569	+	72	Protein_2549	hypothetical protein	-
HA034_RS13285	2642758..2644305	+	1548	WP_000727772.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
HA034_RS13290	2644491..2644958	+	468	WP_000153347.1	SRPBCC domain-containing protein	-
HA034_RS13295	2645042..2645224	+	183	WP_000230292.1	hypothetical protein	-
HA034_RS13300	2645441..2646265	+	825	WP_000572038.1	formate/nitrite transporter family protein	-
HA034_RS13305	2646499..2647035	+	537	WP_000169317.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T156669 WP_000113265.1 NZ_CP053356:2642197-2642463 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T156669 NZ_CP069069:704799-705200 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT156669 WP_000584499.1 NZ_CP053356:2641946-2642197 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT156669 NZ_CP069069:704557-704802 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Structures

Toxin

• PDB: 7BWF

Antitoxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7BWF
• PDB: 6L8E
• AlphaFold DB: T1YB60