Detailed information of TA system TA156667

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2616740..2616924
• Replicon: chromosome
• Accession: NZ_CP053356
• Organism: Staphylococcus aureus strain 14507

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: HA034_RS13140
• Protein ID: WP_000482652.1
• Coordinates: 2616740..2616847 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2616864..2616924 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA034_RS13115	2612102..2612575	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
HA034_RS13120	2612698..2613909	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
HA034_RS13125	2614091..2614750	-	660	WP_000831298.1	membrane protein	-
HA034_RS13130	2614810..2615952	-	1143	WP_001176863.1	glycerate kinase	-
HA034_RS13135	2616220..2616606	+	387	WP_000779360.1	flippase GtxA	-
HA034_RS13140	2616740..2616847	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2616864..2616924	-	61	-	-	Antitoxin
HA034_RS13145	2617550..2619313	+	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
HA034_RS13150	2619338..2621071	+	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
HA034_RS13155	2621302..2621469	+	168	Protein_2524	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T156667 WP_000482652.1 NZ_CP053356:2616740-2616847 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T156667 NZ_CP069069:c696540-696148 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT156667 NZ_CP053356:c2616924-2616864 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin