Detailed information of TA system TA156662

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 727718..728297
• Replicon: chromosome
• Accession: NZ_CP053356
• Organism: Staphylococcus aureus strain 14507

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: HA034_RS04180
• Protein ID: WP_001025401.1
• Coordinates: 727718..727963 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	727932..728297 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA034_RS04130	723969..724583	+	615	WP_000191466.1	hypothetical protein	-
HA034_RS04135	724580..724726	-	147	WP_001794606.1	hypothetical protein	-
HA034_RS04140	724762..724944	-	183	WP_000705240.1	hypothetical protein	-
HA034_RS04145	725014..725745	-	732	WP_000511090.1	XRE family transcriptional regulator	-
HA034_RS04150	725897..726109	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
HA034_RS04155	726157..726600	+	444	WP_000435357.1	hypothetical protein	-
HA034_RS04160	726615..726764	+	150	WP_000771849.1	hypothetical protein	-
HA034_RS04165	726805..727017	-	213	WP_000362644.1	hypothetical protein	-
HA034_RS04170	727087..727284	+	198	WP_031898325.1	hypothetical protein	-
HA034_RS04175	727271..727651	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
HA034_RS04180	727718..727963	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
HA034_RS04185	727932..728297	-	366	WP_001128433.1	hypothetical protein	Antitoxin
HA034_RS04190	728352..728567	+	216	WP_001097552.1	hypothetical protein	-
HA034_RS04195	728592..728855	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
HA034_RS04200	728868..729029	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
HA034_RS04205	729108..729431	+	324	WP_000174998.1	hypothetical protein	-
HA034_RS04210	729446..729808	+	363	WP_000985971.1	hypothetical protein	-
HA034_RS04215	729805..730971	+	1167	WP_000762538.1	DUF2800 domain-containing protein	-
HA034_RS04220	730997..731554	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T156662 WP_001025401.1 NZ_CP053356:727718-727963 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T156662 NZ_CP069069:365085-365387 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT156662 NZ_CP053356:c728297-727932 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin