Detailed information of TA system TA156660

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 395182..395362
• Replicon: chromosome
• Accession: NZ_CP053356
• Organism: Staphylococcus aureus strain 14507

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: HA034_RS02520
• Protein ID: WP_001801861.1
• Coordinates: 395267..395362 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	395182..395239 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA034_RS02490	390891..391025	+	135	WP_001791797.1	hypothetical protein	-
HA034_RS02495	391189..392745	+	1557	WP_000028669.1	type I restriction-modification system subunit M	-
HA034_RS02500	392738..393967	+	1230	WP_000072627.1	restriction endonuclease subunit S	-
HA034_RS02505	394419..394913	+	495	Protein_423	transposase	-
HA034_RS02510	394904..395065	+	162	Protein_424	transposase	-
HA034_RS02515	395043..395144	-	102	WP_001792025.1	hypothetical protein	-
-	395182..395239	+	58	-	-	Antitoxin
HA034_RS02520	395267..395362	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
HA034_RS02525	395507..396519	+	1013	Protein_427	IS3 family transposase	-
HA034_RS02530	396717..397289	-	573	WP_000414216.1	hypothetical protein	-
HA034_RS02535	397390..397731	-	342	WP_000627540.1	DUF3969 family protein	-
HA034_RS02540	397772..398398	-	627	WP_000669024.1	hypothetical protein	-
HA034_RS02545	398473..399468	-	996	WP_000070642.1	DUF4352 domain-containing protein	-
HA034_RS02550	399549..400199	-	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	368347..419381	51034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-122)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T156660 WP_001801861.1 NZ_CP053356:c395362-395267 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T156660 NZ_CP069069:71513-71914 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin

Nucleotide

• Length: 58 bp

>AT156660 NZ_CP053356:395182-395239 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin