Detailed information of TA system TA156656

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 195683..196021
• Replicon: chromosome
• Accession: NZ_CP053356
• Organism: Staphylococcus aureus strain 14507

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: HA034_RS01185
• Protein ID: WP_011447039.1
• Coordinates: 195683..195859 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	195847..196021 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA034_RS01165	190918..194703	+	3786	WP_000582154.1	hypothetical protein	-
HA034_RS01170	194693..194845	+	153	WP_001153681.1	hypothetical protein	-
HA034_RS01175	194892..195179	+	288	WP_001040261.1	hypothetical protein	-
HA034_RS01180	195237..195533	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
HA034_RS01185	195683..195859	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	195847..196021	-	175	-	-	Antitoxin
HA034_RS01195	196071..196325	+	255	WP_000611512.1	phage holin	-
HA034_RS01200	196337..197092	+	756	WP_000861038.1	CHAP domain-containing protein	-
HA034_RS01205	197283..197774	+	492	WP_000919350.1	staphylokinase	-
HA034_RS01210	198424..198759	+	336	Protein_203	SH3 domain-containing protein	-
HA034_RS01215	198854..199303	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
HA034_RS01220	199988..200338	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
HA034_RS01225	200391..200651	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	146815..200338	53523

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T156656 WP_011447039.1 NZ_CP053356:195683-195859 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T156656 NZ_CP069068:c3714207-3713779 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Nucleotide

• Length: 175 bp

>AT156656 NZ_CP053356:c196021-195847 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin