Detailed information of TA system TA156644

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2573864..2574046
• Replicon: plasmid unnamed
• Accession: NZ_CP053353
• Organism: Staphylococcus aureus strain 16405

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: HA035_RS12615
• Protein ID: WP_001801861.1
• Coordinates: 2573864..2573959 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2573987..2574046 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA035_RS12575	2569524..2570150	+	627	WP_000669046.1	hypothetical protein	-
HA035_RS12580	2570191..2570535	+	345	WP_000627551.1	DUF3969 family protein	-
HA035_RS12585	2570633..2571184	+	552	WP_000414205.1	hypothetical protein	-
HA035_RS12590	2571402..2572043	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
HA035_RS12595	2572157..2572342	-	186	WP_000809857.1	hypothetical protein	-
HA035_RS12600	2572344..2572520	-	177	WP_000375476.1	hypothetical protein	-
HA035_RS12605	2572531..2572914	-	384	WP_000070811.1	hypothetical protein	-
HA035_RS12610	2573518..2573661	-	144	WP_001549059.1	transposase	-
HA035_RS12615	2573864..2573959	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2573987..2574046	-	60	-	-	Antitoxin
HA035_RS12620	2574082..2574183	+	102	WP_001791893.1	hypothetical protein	-
HA035_RS12625	2574161..2574337	-	177	Protein_2484	transposase	-
HA035_RS12630	2574531..2574908	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	mecA / blaZ / dfrG	hysA / sbi / hlgA / hlgC / hlgB / bpsC / fnbB / fnbA / aur / icaR / icaA / icaD / icaB / icaC / lip / adsA / adsA / spa / cap8A / cap8B / cap8C / cap8D / cap8D / cap8E / cap8E / cap8F / cap8G / cap8L / cap8M / cap8N / cap8O / cap8P / coa / esxA / esaA / essA / esaB / essB / essC / esxC / esxB / esaE / esxD / esaD / esaG4 / esaG1 / esaG7 / esaG3 / esaG3 / esaG4 / esaG9 / geh / clpC / tufA / sdrC / sdrD / sdrE / clpP / vWbp / sspC / sspB / sspA / isdB / isdA / isdC / isdD / isdE / isdF / srtB / isdG / hly/hla / acpXL / katA / ebp / gnd / lukD / hlgA / map / hlb / scn / sak / sea / hlb / groEL / hld	1..2868068	2868068
	-	flank	IS/Tn	-	-	2568826..2569311	485

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T156644 WP_001801861.1 NZ_CP053353:2573864-2573959 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T156644 NZ_CP069068:2873042-2873419 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin

Nucleotide

• Length: 60 bp

>AT156644 NZ_CP053353:c2574046-2573987 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin