Detailed information of TA system TA156640

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 374163..374347
• Replicon: plasmid unnamed
• Accession: NZ_CP053353
• Organism: Staphylococcus aureus strain 16405

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: HA035_RS01965
• Protein ID: WP_000482650.1
• Coordinates: 374240..374347 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	374163..374223 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA035_RS01950	369693..369860	-	168	WP_001789936.1	hypothetical protein	-
HA035_RS01955	370091..371824	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
HA035_RS01960	371849..373612	-	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
-	374163..374223	+	61	-	-	Antitoxin
HA035_RS01965	374240..374347	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
HA035_RS01970	374481..374867	-	387	WP_000779358.1	flippase GtxA	-
HA035_RS01975	375135..376277	+	1143	WP_001176863.1	glycerate kinase	-
HA035_RS01980	376337..376996	+	660	WP_000831298.1	membrane protein	-
HA035_RS01985	377178..378389	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
HA035_RS01990	378512..378985	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	mecA / blaZ / dfrG	hysA / sbi / hlgA / hlgC / hlgB / bpsC / fnbB / fnbA / aur / icaR / icaA / icaD / icaB / icaC / lip / adsA / adsA / spa / cap8A / cap8B / cap8C / cap8D / cap8D / cap8E / cap8E / cap8F / cap8G / cap8L / cap8M / cap8N / cap8O / cap8P / coa / esxA / esaA / essA / esaB / essB / essC / esxC / esxB / esaE / esxD / esaD / esaG4 / esaG1 / esaG7 / esaG3 / esaG3 / esaG4 / esaG9 / geh / clpC / tufA / sdrC / sdrD / sdrE / clpP / vWbp / sspC / sspB / sspA / isdB / isdA / isdC / isdD / isdE / isdF / srtB / isdG / hly/hla / acpXL / katA / ebp / gnd / lukD / hlgA / map / hlb / scn / sak / sea / hlb / groEL / hld	1..2868068	2868068

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T156640 WP_000482650.1 NZ_CP053353:c374347-374240 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T156640 NZ_CP069068:c2408520-2408203 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT156640 NZ_CP053353:374163-374223 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin