Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2122687..2123257 Replicon chromosome
Accession NZ_CP053344
Organism Herbiconiux sp. SALV-R1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HL652_RS10180 Protein ID WP_171705218.1
Coordinates 2122976..2123257 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HL652_RS10175 Protein ID WP_171705217.1
Coordinates 2122687..2122989 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HL652_RS10155 2118693..2118899 - 207 WP_171705213.1 cold-shock protein -
HL652_RS10160 2118847..2120064 + 1218 WP_171705214.1 prolipoprotein diacylglyceryl transferase -
HL652_RS10165 2120069..2120857 - 789 WP_171705215.1 hypothetical protein -
HL652_RS10170 2120986..2122545 - 1560 WP_171705216.1 FAD-binding oxidoreductase -
HL652_RS10175 2122687..2122989 - 303 WP_171705217.1 HigA family addiction module antidote protein Antitoxin
HL652_RS10180 2122976..2123257 - 282 WP_171705218.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HL652_RS10185 2123321..2123962 - 642 WP_171705219.1 LysE family translocator -
HL652_RS10190 2123980..2124441 - 462 WP_171705220.1 aromatic ring-opening dioxygenase LigA -
HL652_RS10195 2124544..2124942 - 399 WP_171707284.1 DUF1801 domain-containing protein -
HL652_RS10200 2124955..2125374 - 420 WP_171705221.1 hypothetical protein -
HL652_RS10205 2125671..2126024 - 354 WP_171705222.1 hypothetical protein -
HL652_RS10210 2126089..2127162 - 1074 WP_171705223.1 redox-regulated ATPase YchF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10956.48 Da        Isoelectric Point: 10.3938

>T156628 WP_171705218.1 NZ_CP053344:c2123257-2122976 [Herbiconiux sp. SALV-R1]
MIRSFGDKNTERLWRRERVRSIDPRIHRVALRKLRQLGSAVVLDDLRAPPGNRLEALRGDRAGQYSIRINDQWRICFVWT
DAGAEEVEIVDYH

Download         Length: 282 bp

>T156628 NZ_CP069068:1777898-1778302 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11120.83 Da        Isoelectric Point: 7.2028

>AT156628 WP_171705217.1 NZ_CP053344:c2122989-2122687 [Herbiconiux sp. SALV-R1]
MTITEKMAPIHPGEVLREDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRAVTADTALRLGRYFGTSAQFWLNLQTKYDL
DLAEDRVSEQIAAITPLKVA

Download         Length: 303 bp

>AT156628 NZ_CP069068:1777689-1777892 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References