Detailed information of TA system TA156598

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4215829..4216087
• Replicon: chromosome
• Accession: NZ_CP053296
• Organism: Escherichia coli strain M1/5

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HLK60_RS20375
• Protein ID: WP_001181672.1
• Coordinates: 4215878..4216087 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4215829..4215886 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLK60_RS20360	4211658..4212917	-	1260	WP_000494929.1	hypothetical protein	-
HLK60_RS20365	4213046..4214539	-	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
HLK60_RS20370	4214559..4215320	-	762	WP_001274832.1	hypothetical protein	-
-	4215829..4215886	-	58	-	-	Antitoxin
HLK60_RS20375	4215878..4216087	+	210	WP_001181672.1	type I toxin-antitoxin system Hok family toxin	Toxin
HLK60_RS20380	4216192..4217322	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HLK60_RS20385	4217411..4219327	-	1917	WP_000516135.1	molecular chaperone DnaK	-
HLK60_RS20390	4219699..4220103	+	405	WP_000843687.1	DUF2541 family protein	-
HLK60_RS20395	4220129..4220842	+	714	WP_001102391.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7757.25 Da
• Isoelectric Point: 9.3680

>T156598 WP_001181672.1 NZ_CP053296:4215878-4216087 [Escherichia coli]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T156598 NZ_CP069067:3793118-3793375 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT156598 NZ_CP053296:c4215886-4215829 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin