Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4681231..4681859 Replicon chromosome
Accession NZ_CP053286
Organism Serratia marcescens strain FZSF02

Toxin (Protein)


Gene name higB Uniprot ID A0A6M5HY34
Locus tag HMI62_RS22510 Protein ID WP_048325546.1
Coordinates 4681231..4681521 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B4GQY7
Locus tag HMI62_RS22515 Protein ID WP_015379150.1
Coordinates 4681536..4681859 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMI62_RS22500 4677644..4679665 + 2022 WP_171404434.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
HMI62_RS22505 4679861..4681000 - 1140 WP_015379148.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
HMI62_RS22510 4681231..4681521 + 291 WP_048325546.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HMI62_RS22515 4681536..4681859 + 324 WP_015379150.1 HigA family addiction module antidote protein Antitoxin
HMI62_RS22520 4681852..4682364 + 513 WP_042785417.1 M48 family metallopeptidase -
HMI62_RS22525 4682414..4683394 + 981 WP_049241481.1 Gfo/Idh/MocA family oxidoreductase -
HMI62_RS22530 4683396..4684127 + 732 WP_004937150.1 glutamine amidotransferase -
HMI62_RS22535 4684383..4685348 + 966 WP_171404770.1 TerC family protein -
HMI62_RS22540 4685611..4686846 + 1236 WP_004937146.1 serine/threonine transporter SstT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11627.31 Da        Isoelectric Point: 10.2325

>T156573 WP_048325546.1 NZ_CP053286:4681231-4681521 [Serratia marcescens]
MIKSFRDRYLEQFYLEGKRSRLIPGVLERQLARKLDILAAAQQERDLHHPTGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Download         Length: 291 bp

>T156573 NZ_CP069067:2221413-2221790 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12141.78 Da        Isoelectric Point: 6.2285

>AT156573 WP_015379150.1 NZ_CP053286:4681536-4681859 [Serratia marcescens]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILGRNITHA

Download         Length: 324 bp

>AT156573 NZ_CP069067:2221832-2222281 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M5HY34

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GQY7

References