Detailed information of TA system TA156531

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2291168..2291539
• Replicon: chromosome
• Accession: NZ_CP053284
• Organism: Escherichia coli strain SCU-104

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: F4VC37
• Locus tag: HHJ22_RS11105
• Protein ID: WP_001317028.1
• Coordinates: 2291345..2291539 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2291168..2291346 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ22_RS11080	2287124..2288497	+	1374	WP_000123737.1	ATP-dependent RNA helicase DbpA	-
HHJ22_RS11085	2288626..2289561	-	936	WP_001157406.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
HHJ22_RS11090	2289613..2290847	-	1235	Protein_2170	DUF3596 domain-containing protein	-
HHJ22_RS11095	2290849..2291064	-	216	WP_000079604.1	excisionase XisR	-
HHJ22_RS11100	2291143..2291352	-	210	WP_000276809.1	double-strand break reduction protein RcbA	-
-	2291168..2291346	+	179	NuclAT_0	-	Antitoxin
-	2291168..2291346	+	179	NuclAT_0	-	Antitoxin
-	2291168..2291346	+	179	NuclAT_0	-	Antitoxin
-	2291168..2291346	+	179	NuclAT_0	-	Antitoxin
HHJ22_RS11105	2291345..2291539	-	195	WP_001317028.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
HHJ22_RS11110	2291595..2292404	-	810	WP_000166319.1	recombination protein RecT	-
HHJ22_RS11115	2292397..2294997	-	2601	Protein_2175	exodeoxyribonuclease VIII	-
HHJ22_RS11120	2295099..2295374	-	276	WP_000632297.1	protein RacC	-
HHJ22_RS11125	2295449..2295619	-	171	WP_016232653.1	phage protein	-
HHJ22_RS11130	2295619..2295840	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2289613..2337056	47443

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7018.89 Da
• Isoelectric Point: 8.9538

>T156531 WP_001317028.1 NZ_CP053284:c2291539-2291345 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T156531 NZ_CP069066:c3050671-3050276 [Mycobacterium tuberculosis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT156531 NZ_CP053284:2291168-2291346 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7L6LHV7

Antitoxin