156467

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2825064..2825666 Replicon chromosome
Accession NZ_CP053258
Organism Escherichia coli strain GF4-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HLY11_RS13155 Protein ID WP_171460044.1
Coordinates 2825355..2825666 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HLY11_RS13150 Protein ID WP_000356397.1
Coordinates 2825064..2825354 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLY11_RS13125 2820992..2821894 + 903 WP_171460041.1 formate dehydrogenase O subunit beta -
HLY11_RS13130 2821891..2822526 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
HLY11_RS13135 2822523..2823452 + 930 WP_000027691.1 formate dehydrogenase accessory protein FdhE -
HLY11_RS13140 2823781..2823999 - 219 WP_171460042.1 ribbon-helix-helix domain-containing protein -
HLY11_RS13145 2824242..2824460 - 219 WP_171460043.1 ribbon-helix-helix domain-containing protein -
HLY11_RS13150 2825064..2825354 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
HLY11_RS13155 2825355..2825666 - 312 WP_171460044.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HLY11_RS13160 2825895..2826803 + 909 WP_171460045.1 alpha/beta hydrolase -
HLY11_RS13165 2826972..2828786 - 1815 WP_171460046.1 hypothetical protein -
HLY11_RS13170 2829201..2830142 - 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
HLY11_RS13175 2830187..2830624 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12204.22 Da        Isoelectric Point: 9.7791

>T156467 WP_171460044.1 NZ_CP053258:c2825666-2825355 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKIRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T156467 NZ_CP069065:c2388132-2387815 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT156467 WP_000356397.1 NZ_CP053258:c2825354-2825064 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT156467 NZ_CP069065:c2388344-2388129 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References