Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1214757..1215345 Replicon chromosome
Accession NZ_CP053256
Organism Helicobacter pylori A45

Toxin (Protein)


Gene name TfiT Uniprot ID A0A6M5U7W9
Locus tag C528_RS05685 Protein ID WP_001917619.1
Coordinates 1214757..1215038 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID A0A6M5U3S5
Locus tag C528_RS05690 Protein ID WP_001917618.1
Coordinates 1215031..1215345 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C528_RS05650 1209968..1210231 + 264 WP_001917625.1 hypothetical protein -
C528_RS05655 1210228..1210527 + 300 WP_000660136.1 hypothetical protein -
C528_RS05660 1210527..1211468 + 942 WP_001917624.1 Flp pilus assembly complex ATPase component TadA -
C528_RS05665 1211465..1211920 + 456 WP_001917623.1 hypothetical protein -
C528_RS05670 1211917..1212207 + 291 WP_001917622.1 hypothetical protein -
C528_RS05675 1212208..1212765 + 558 WP_001917621.1 hypothetical protein -
C528_RS05680 1212766..1214493 + 1728 WP_001917620.1 type IV secretory system conjugative DNA transfer family protein -
C528_RS05685 1214757..1215038 - 282 WP_001917619.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
C528_RS05690 1215031..1215345 - 315 WP_001917618.1 hypothetical protein Antitoxin
C528_RS05695 1215629..1217542 + 1914 WP_171407247.1 relaxase/mobilization nuclease domain-containing protein -
C528_RS05700 1217567..1218751 - 1185 WP_001917617.1 hypothetical protein -
C528_RS05705 1218783..1219067 - 285 WP_000394639.1 hypothetical protein -
C528_RS05710 1219149..1219805 - 657 WP_001917616.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10877.77 Da        Isoelectric Point: 9.5726

>T156444 WP_001917619.1 NZ_CP053256:c1215038-1214757 [Helicobacter pylori A45]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEVKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T156444 NZ_CP069065:c753739-753302 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12168.59 Da        Isoelectric Point: 4.9439

>AT156444 WP_001917618.1 NZ_CP053256:c1215345-1215031 [Helicobacter pylori A45]
MSDIITDYSQYSEKQLHNFLNAIEKQWLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT156444 NZ_CP069065:c753192-752947 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCCCTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M5U7W9

Antitoxin

Source ID Structure
AlphaFold DB A0A6M5U3S5

References