Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 7536..8182 Replicon plasmid pSCU-204-2
Accession NZ_CP053252
Organism Escherichia coli strain SCU-204

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HHJ42_RS24840 Protein ID WP_000269912.1
Coordinates 7835..8182 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HHJ42_RS24835 Protein ID WP_171274533.1
Coordinates 7536..7835 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ42_RS24800 2918..3166 + 249 WP_000730008.1 hypothetical protein -
HHJ42_RS24805 3992..4186 + 195 WP_167787531.1 ash family protein -
HHJ42_RS24810 4297..4488 + 192 WP_004105259.1 hypothetical protein -
HHJ42_RS24815 4485..5627 + 1143 WP_171274532.1 ORF6N domain-containing protein -
HHJ42_RS24820 6234..6506 - 273 WP_089591621.1 helix-turn-helix domain-containing protein -
HHJ42_RS24825 6570..6950 - 381 WP_000061763.1 hypothetical protein -
HHJ42_RS24830 7218..7502 + 285 WP_001673380.1 hypothetical protein -
HHJ42_RS24835 7536..7835 - 300 WP_171274533.1 XRE family transcriptional regulator Antitoxin
HHJ42_RS24840 7835..8182 - 348 WP_000269912.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ42_RS24845 8427..8690 - 264 WP_000424604.1 hypothetical protein -
HHJ42_RS24850 8714..9001 - 288 WP_000356589.1 hypothetical protein -
HHJ42_RS24855 9645..10481 - 837 WP_024171747.1 replication initiator protein RepA -
HHJ42_RS24860 11107..11652 + 546 WP_001704996.1 transferase -
HHJ42_RS24865 11616..12233 - 618 WP_001523080.1 tail fiber assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..47276 47276


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13545.51 Da        Isoelectric Point: 8.8337

>T156443 WP_000269912.1 NZ_CP053252:c8182-7835 [Escherichia coli]
MWTVLFSQRFDDWLNEQEDALQEKVLADLKKLQVYGPELPRPYADTVKGSRYKNMKELRVQFSGRPIRAFYAFDPIRRAI
VLCAGDKSNDKRFYEKLVRIAEDEFAAHLNTLESK

Download         Length: 348 bp

>T156443 NZ_CP069065:c752960-752652 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGT
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11099.93 Da        Isoelectric Point: 5.8899

>AT156443 WP_171274533.1 NZ_CP053252:c7835-7536 [Escherichia coli]
MRTLDEVIASRSPESQTRIKEMADEMILEVGLQMMREELQLSQKQVAEAMGISQPAVTKLEQRGNDLKLATLKRYVEAMG
GKLSLDVELPTGKRVAFHV

Download         Length: 300 bp

>AT156443 NZ_CP069065:c753192-752947 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCCCTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References