Detailed information of TA system TA156422

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1415288..1415546
• Replicon: chromosome
• Accession: NZ_CP053251
• Organism: Escherichia coli strain SCU-204

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HHJ42_RS06760
• Protein ID: WP_001181672.1
• Coordinates: 1415288..1415497 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1415489..1415546 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ42_RS06740	1410530..1411243	-	714	WP_001102391.1	acidic protein MsyB	-
HHJ42_RS06745	1411269..1411673	-	405	WP_000843687.1	DUF2541 family protein	-
HHJ42_RS06750	1412045..1413963	+	1919	Protein_1308	molecular chaperone DnaK	-
HHJ42_RS06755	1414052..1415167	+	1116	WP_052976956.1	molecular chaperone DnaJ	-
HHJ42_RS06760	1415288..1415497	-	210	WP_001181672.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	1415489..1415546	+	58	-	-	Antitoxin
HHJ42_RS06765	1416055..1416816	+	762	WP_001274832.1	hypothetical protein	-
HHJ42_RS06770	1416836..1418329	+	1494	WP_001774152.1	sulfatase-like hydrolase/transferase	-
HHJ42_RS06775	1418458..1419717	+	1260	WP_000494929.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7757.25 Da
• Isoelectric Point: 9.3680

>T156422 WP_001181672.1 NZ_CP053251:c1415497-1415288 [Escherichia coli]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T156422 NZ_CP069064:c3119311-3118919 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT156422 NZ_CP053251:1415489-1415546 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin