Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3029253..3029946 Replicon chromosome
Accession NZ_CP053247
Organism Escherichia coli strain SCU-482

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag HHJ51_RS14770 Protein ID WP_000415585.1
Coordinates 3029253..3029549 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HHJ51_RS14775 Protein ID WP_000650107.1
Coordinates 3029551..3029946 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ51_RS14740 3024375..3025566 + 1192 Protein_2872 Hcp family type VI secretion system effector -
HHJ51_RS14745 3025630..3025918 + 289 Protein_2873 DUF2645 family protein -
HHJ51_RS14750 3025964..3027313 - 1350 WP_000673357.1 two-component system sensor histidine kinase QseC -
HHJ51_RS14755 3027310..3027969 - 660 WP_001221493.1 two-component system response regulator QseB -
HHJ51_RS14760 3028121..3028513 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HHJ51_RS14765 3028566..3029048 + 483 WP_000183505.1 transcriptional regulator -
HHJ51_RS14770 3029253..3029549 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
HHJ51_RS14775 3029551..3029946 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HHJ51_RS14780 3030079..3031686 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HHJ51_RS14785 3031824..3034082 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T156401 WP_000415585.1 NZ_CP053247:3029253-3029549 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T156401 NZ_CP069064:1964289-1964537 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT156401 WP_000650107.1 NZ_CP053247:3029551-3029946 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT156401 NZ_CP069064:1964077-1964289 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References