Detailed information of TA system TA156390

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1431125..1431383
• Replicon: chromosome
• Accession: NZ_CP053247
• Organism: Escherichia coli strain SCU-482

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HHJ51_RS07110
• Protein ID: WP_000935262.1
• Coordinates: 1431174..1431383 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1431125..1431182 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ51_RS07090	1426740..1427699	+	960	WP_000871674.1	hypothetical protein	-
HHJ51_RS07095	1427737..1428636	-	900	WP_001300855.1	transcriptional activator NhaR	-
HHJ51_RS07100	1428702..1429868	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
HHJ51_RS07105	1430314..1431011	+	698	Protein_1393	IS1 family transposase	-
-	1431125..1431182	-	58	-	-	Antitoxin
HHJ51_RS07110	1431174..1431383	+	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
HHJ51_RS07115	1431487..1432617	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HHJ51_RS07120	1432706..1434622	-	1917	WP_000516135.1	molecular chaperone DnaK	-
HHJ51_RS07125	1434998..1435402	+	405	WP_000843584.1	DUF2541 family protein	-
HHJ51_RS07130	1435428..1436141	+	714	WP_001102367.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	espX1	1422410..1431383	8973

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T156390 WP_000935262.1 NZ_CP053247:1431174-1431383 [Escherichia coli]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T156390 NZ_CP069064:838607-839035 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CTGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT156390 NZ_CP053247:c1431182-1431125 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin