Detailed information of TA system TA156360

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1643899..1644156
• Replicon: chromosome
• Accession: NZ_CP053245
• Organism: Escherichia coli strain SCU-485

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: S1E8G5
• Locus tag: HHJ54_RS07705
• Protein ID: WP_001135732.1
• Coordinates: 1643899..1644051 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	1644108..1644156 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ54_RS07680	1639997..1640656	+	660	WP_000747625.1	OmpA family lipoprotein	-
HHJ54_RS07685	1640760..1641734	+	975	WP_000805027.1	glyoxylate/hydroxypyruvate reductase GhrB	-
HHJ54_RS07690	1641784..1642494	-	711	WP_000190516.1	DUF3053 domain-containing protein	-
HHJ54_RS07695	1642928..1643218	+	291	WP_000455798.1	HTH-type transcriptional regulator	-
HHJ54_RS07700	1643499..1643711	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HHJ54_RS07705	1643899..1644051	-	153	WP_001135732.1	type I toxin-antitoxin system toxin HokA	Toxin
-	1644108..1644156	+	49	-	-	Antitoxin
HHJ54_RS07710	1644374..1646443	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
HHJ54_RS07715	1646453..1647364	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HHJ54_RS07720	1647459..1647767	-	309	WP_000980157.1	YsaB family lipoprotein	-
HHJ54_RS07725	1647942..1648937	+	996	WP_001182669.1	O-acetyltransferase WecH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5998.28 Da
• Isoelectric Point: 7.7169

>T156360 WP_001135732.1 NZ_CP053245:c1644051-1643899 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T156360 NZ_CP069063:c2875856-2875461 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin

Nucleotide

• Length: 49 bp

>AT156360 NZ_CP053245:1644108-1644156 [Escherichia coli]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: S1E8G5

Antitoxin