Detailed information of TA system TA156356

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 774186..774432
• Replicon: chromosome
• Accession: NZ_CP053245
• Organism: Escherichia coli strain SCU-485

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: HHJ54_RS03570
• Protein ID: WP_000956458.1
• Coordinates: 774186..774338 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	774380..774432 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ54_RS03545	769457..769780	-	324	WP_001246113.1	DUF3561 family protein	-
HHJ54_RS03550	769830..770435	-	606	WP_001173653.1	adenylyl-sulfate kinase	-
HHJ54_RS03555	770435..771862	-	1428	WP_001090357.1	sulfate adenylyltransferase subunit CysN	-
HHJ54_RS03560	771864..772772	-	909	WP_000372392.1	sulfate adenylyltransferase subunit CysD	-
HHJ54_RS03565	773024..774061	+	1038	WP_000490435.1	alkaline phosphatase isozyme conversion aminopeptidase	-
HHJ54_RS03570	774186..774338	-	153	WP_000956458.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	774380..774432	+	53	-	-	Antitoxin
HHJ54_RS03575	774603..775337	-	735	WP_000039865.1	phosphoadenosine phosphosulfate reductase	-
HHJ54_RS03580	775411..777123	-	1713	WP_001290708.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
HHJ54_RS03585	777123..778922	-	1800	WP_000211918.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T156356 WP_000956458.1 NZ_CP053245:c774338-774186 [Escherichia coli]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T156356 NZ_CP069063:2813389-2813814 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin

Nucleotide

• Length: 53 bp

>AT156356 NZ_CP053245:774380-774432 [Escherichia coli]
TTAGGTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin