Detailed information of TA system TA156308

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4202473..4202731
• Replicon: chromosome
• Accession: NZ_CP053231
• Organism: Escherichia coli strain SCU-306

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HHJ44_RS20335
• Protein ID: WP_001181672.1
• Coordinates: 4202473..4202682 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4202674..4202731 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ44_RS20315	4197718..4198431	-	714	WP_001102393.1	acidic protein MsyB	-
HHJ44_RS20320	4198457..4198861	-	405	WP_000843687.1	DUF2541 family protein	-
HHJ44_RS20325	4199233..4201149	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HHJ44_RS20330	4201238..4202368	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HHJ44_RS20335	4202473..4202682	-	210	WP_001181672.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	4202674..4202731	+	58	-	-	Antitoxin
HHJ44_RS20340	4203237..4203998	+	762	WP_001274823.1	hypothetical protein	-
HHJ44_RS20345	4204018..4205511	+	1494	WP_001350775.1	sulfatase-like hydrolase/transferase	-
HHJ44_RS20350	4205640..4206899	+	1260	WP_000494924.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7757.25 Da
• Isoelectric Point: 9.3680

>T156308 WP_001181672.1 NZ_CP053231:c4202682-4202473 [Escherichia coli]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T156308 NZ_CP069062:c3138491-3138099 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT156308 NZ_CP053231:4202674-4202731 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin