Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2696..3281 Replicon plasmid unnamed3
Accession NZ_CP053221
Organism Acinetobacter baumannii strain DT01139C

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HLG77_RS18815 Protein ID WP_179993844.1
Coordinates 2961..3281 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HLG77_RS18810 Protein ID WP_179993842.1
Coordinates 2696..2968 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLG77_RS18795 1..915 + 915 WP_179993839.1 replication initiation protein RepM -
HLG77_RS18800 983..1528 + 546 WP_179993841.1 plasmid replication DNA-binding protein -
HLG77_RS18805 1789..2163 + 375 WP_179993849.1 rod shape-determining protein -
HLG77_RS18810 2696..2968 - 273 WP_179993842.1 helix-turn-helix domain-containing protein Antitoxin
HLG77_RS18815 2961..3281 - 321 WP_179993844.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HLG77_RS18820 3497..4990 + 1494 WP_179993847.1 phosphoethanolamine transferase -
HLG77_RS18825 5018..5779 + 762 WP_179993834.1 hypothetical protein -
HLG77_RS18830 5870..6802 + 933 WP_119685952.1 IS5 family transposase -
HLG77_RS18835 6883..7464 - 582 WP_179993835.1 histidine phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..9613 9613
- flank IS/Tn - - 5870..6802 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12188.02 Da        Isoelectric Point: 6.9502

>T156278 WP_179993844.1 NZ_CP053221:c3281-2961 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGICKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSMKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T156278 NZ_CP069062:c1231940-1231629 [Mycobacterium tuberculosis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10125.60 Da        Isoelectric Point: 8.6797

>AT156278 WP_179993842.1 NZ_CP053221:c2968-2696 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRNEMKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILNAHPTLI

Download         Length: 273 bp

>AT156278 NZ_CP069062:c1232260-1231940 [Mycobacterium tuberculosis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References