Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 704618..705311 Replicon chromosome
Accession NZ_CP053211
Organism Escherichia coli strain QDFD216

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HJ589_RS03465 Protein ID WP_000415584.1
Coordinates 704618..704914 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HJ589_RS03470 Protein ID WP_000650107.1
Coordinates 704916..705311 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ589_RS03430 (699706) 699706..700020 - 315 WP_000958598.1 putative quinol monooxygenase -
HJ589_RS03435 (700051) 700051..700632 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HJ589_RS03440 (700951) 700951..701283 + 333 WP_000917684.1 DUF2645 family protein -
HJ589_RS03445 (701329) 701329..702678 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HJ589_RS03450 (702675) 702675..703334 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HJ589_RS03455 (703486) 703486..703878 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HJ589_RS03460 (703931) 703931..704413 + 483 WP_114505457.1 GyrI-like domain-containing protein -
HJ589_RS03465 (704618) 704618..704914 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HJ589_RS03470 (704916) 704916..705311 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HJ589_RS03475 (705444) 705444..707051 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HJ589_RS03480 (707189) 707189..709447 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T156249 WP_000415584.1 NZ_CP053211:704618-704914 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T156249 NZ_CP069046:c5423997-5423614 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT156249 WP_000650107.1 NZ_CP053211:704916-705311 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT156249 NZ_CP069046:c5424239-5423997 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References