Detailed information of TA system TA156218

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2492926..2493110
• Replicon: chromosome
• Accession: NZ_CP053185
• Organism: Staphylococcus aureus strain Guangzhou-SAU749

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: HLG72_RS12445
• Protein ID: WP_000482647.1
• Coordinates: 2493003..2493110 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2492926..2492986 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLG72_RS12425	2488436..2488603	-	168	WP_031845053.1	hypothetical protein	-
HLG72_RS12430	2488834..2490567	-	1734	WP_000488493.1	ABC transporter ATP-binding protein/permease	-
HLG72_RS12435	2490643..2492355	-	1713	WP_001064821.1	ABC transporter ATP-binding protein/permease	-
HLG72_RS12440	2492809..2492976	-	168	WP_000301893.1	hypothetical protein	-
-	2492926..2492986	+	61	-	-	Antitoxin
HLG72_RS12445	2493003..2493110	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
HLG72_RS12450	2493243..2493629	-	387	WP_000779353.1	flippase GtxA	-
HLG72_RS12455	2493897..2495039	+	1143	WP_001176863.1	glycerate kinase	-
HLG72_RS12460	2495099..2495758	+	660	WP_000831298.1	membrane protein	-
HLG72_RS12465	2495941..2497152	+	1212	WP_001191921.1	multidrug effflux MFS transporter	-
HLG72_RS12470	2497275..2497748	-	474	WP_000456483.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T156218 WP_000482647.1 NZ_CP053185:c2493110-2493003 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T156218 NZ_CP068983:391987-392439 [Paradevosia shaoguanensis]
GTGAGCGGCTACCTGCTGGATACCAACGTCATCTCGATGCTGTCCCCGTCCCGTGCAGACGCCCCTGCCGGCTTCCTCGC
CTGGCTGGACGAACGGGACGCCGAAGATCAGCTCTTCCTCTCGGTCGTTACCATCCACGAAATCGAAAAGGGCATCGGCC
TTCTCGAAAGCCGCAAGGTTGAGGCAAAGGCCAGGGCCTTGCGCCTCTGGCTCTCGGGCCTCGTCTCGACTTACGACGAT
CGCATCCTCCCCATCGATGCCGCTGTCGCCTCACTGTCGGGCAGGCTGGAGGCCGCTGCGTCGAGCGCGGGCCATGCGCC
CGGCATGGCAGACGCGCTGATCGCCGGCACGGCAAGCGCTCACGAACTGACACTCGTCACCCGCAACCTCAGGCACTTCG
AACCCTTCGGGATCGCGCTTCTCGCCCCTGAAAACTGCCGGCCCGGCTCCTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT156218 NZ_CP053185:2492926-2492986 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin