Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2467655..2468172 Replicon chromosome
Accession NZ_CP053185
Organism Staphylococcus aureus strain Guangzhou-SAU749

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag HLG72_RS12305 Protein ID WP_000113263.1
Coordinates 2467655..2467921 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag HLG72_RS12310 Protein ID WP_000584499.1
Coordinates 2467921..2468172 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLG72_RS12280 2462915..2463451 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
HLG72_RS12285 2463864..2464688 - 825 WP_000594633.1 formate/nitrite transporter family protein -
HLG72_RS12290 2464892..2465074 - 183 WP_000079140.1 hypothetical protein -
HLG72_RS12295 2465161..2465628 - 468 WP_000153338.1 SRPBCC domain-containing protein -
HLG72_RS12300 2465814..2467361 - 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HLG72_RS12305 2467655..2467921 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
HLG72_RS12310 2467921..2468172 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HLG72_RS12315 2468346..2468437 - 92 Protein_2379 hypothetical protein -
HLG72_RS12320 2468444..2469043 - 600 WP_000162810.1 DsbA family protein -
HLG72_RS12325 2469062..2469424 - 363 WP_000819839.1 DUF4467 domain-containing protein -
HLG72_RS12330 2469679..2470929 + 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
HLG72_RS12335 2471026..2471757 - 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
HLG72_RS12340 2471754..2472473 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T156217 WP_000113263.1 NZ_CP053185:c2467921-2467655 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T156217 NZ_CP068982:c2263189-2263013 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT156217 WP_000584499.1 NZ_CP053185:c2468172-2467921 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT156217 NZ_CP068982:2263130-2263230 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTATGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References