Detailed information of TA system TA156215

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2203945..2204208
• Replicon: chromosome
• Accession: NZ_CP053185
• Organism: Staphylococcus aureus strain Guangzhou-SAU749

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HLG72_RS10955
• Protein ID: WP_001802298.1
• Coordinates: 2204104..2204208 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2203945..2204109 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLG72_RS10935	2200182..2200847	-	666	WP_001024088.1	SDR family oxidoreductase	-
HLG72_RS10940	2200999..2201319	+	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
HLG72_RS10945	2201321..2202298	+	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
HLG72_RS10950	2202564..2203655	+	1092	WP_170833574.1	transcriptional regulator	-
-	2203945..2204109	+	165	-	-	Antitoxin
HLG72_RS10955	2204104..2204208	-	105	WP_001802298.1	hypothetical protein	Toxin
HLG72_RS10960	2204369..2204852	-	484	Protein_2117	recombinase family protein	-
HLG72_RS10965	2204895..2206031	-	1137	Protein_2118	SAP domain-containing protein	-
HLG72_RS10970	2206320..2206412	+	93	WP_031844941.1	hypothetical protein	-
HLG72_RS10975	2207107..2207964	-	858	WP_000370919.1	Cof-type HAD-IIB family hydrolase	-
HLG72_RS10980	2208032..2208814	-	783	WP_000908190.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T156215 WP_001802298.1 NZ_CP053185:c2204208-2204104 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T156215 NZ_CP068982:c1305596-1304850 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTATATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTAGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAGCCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT156215 NZ_CP053185:2203945-2204109 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin