Detailed information of TA system TA156206

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF3/-
• Location: 370918..371366
• Replicon: chromosome
• Accession: NZ_CP053185
• Organism: Staphylococcus aureus strain Guangzhou-SAU749

Toxin (Protein)

• Gene name: holin
• Uniprot ID: A0A853P973
• Locus tag: HLG72_RS01770
• Protein ID: WP_000387656.1
• Coordinates: 371064..371366 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	370918..370984 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLG72_RS01740	366013..369695	+	3683	Protein_345	hypothetical protein	-
HLG72_RS01745	369682..369834	+	153	WP_001181555.1	hypothetical protein	-
HLG72_RS01750	369881..370155	+	275	Protein_347	hypothetical protein	-
HLG72_RS01755	370229..370525	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
HLG72_RS01760	370718..370865	+	148	Protein_349	putative holin-like toxin	-
HLG72_RS01765	370909..371013	-	105	Protein_350	hypothetical protein	-
-	370918..370984	-	67	NuclAT_0	-	Antitoxin
-	370918..370984	-	67	NuclAT_0	-	Antitoxin
-	370918..370984	-	67	NuclAT_0	-	Antitoxin
-	370918..370984	-	67	NuclAT_0	-	Antitoxin
HLG72_RS01770	371064..371366	+	303	WP_000387656.1	phage holin	Toxin
HLG72_RS01775	371378..372834	+	1457	Protein_352	N-acetylmuramoyl-L-alanine amidase	-
HLG72_RS01780	373080..373232	+	153	WP_001788502.1	hypothetical protein	-
HLG72_RS01785	373303..373414	+	112	Protein_354	hypothetical protein	-
HLG72_RS01790	373416..373602	+	187	Protein_355	hypothetical protein	-
HLG72_RS01795	373951..374876	+	926	Protein_356	hypothetical protein	-
HLG72_RS01800	375099..375282	+	184	Protein_357	hypothetical protein	-
HLG72_RS01805	375279..375965	+	687	Protein_358	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	333424..373607	40183

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (3-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11177.94 Da
• Isoelectric Point: 9.6587

>T156206 WP_000387656.1 NZ_CP053185:371064-371366 [Staphylococcus aureus]
MEAKVMARYVVLILALVNQFLANKGISPIPVDEESISSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T156206 NZ_CP068972:1898843-1898945 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 67 bp

>AT156206 NZ_CP053185:c370984-370918 [Staphylococcus aureus]
ATAAATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCT

Structures

Toxin

• AlphaFold DB: A0A853P973

Antitoxin