Detailed information of TA system TA156203

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2448489..2448673
• Replicon: chromosome
• Accession: NZ_CP053183
• Organism: Staphylococcus aureus strain Guangzhou-SAU071

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: HLB24_RS12075
• Protein ID: WP_000482647.1
• Coordinates: 2448566..2448673 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2448489..2448549 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB24_RS12055	2443999..2444166	-	168	WP_031845053.1	hypothetical protein	-
HLB24_RS12060	2444397..2446130	-	1734	WP_000488493.1	ABC transporter ATP-binding protein/permease	-
HLB24_RS12065	2446206..2447918	-	1713	WP_001064821.1	ABC transporter ATP-binding protein/permease	-
HLB24_RS12070	2448372..2448539	-	168	WP_000301893.1	hypothetical protein	-
-	2448489..2448549	+	61	-	-	Antitoxin
HLB24_RS12075	2448566..2448673	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
HLB24_RS12080	2448806..2449192	-	387	WP_000779353.1	flippase GtxA	-
HLB24_RS12085	2449460..2450602	+	1143	WP_001176863.1	glycerate kinase	-
HLB24_RS12090	2450662..2451321	+	660	WP_000831298.1	membrane protein	-
HLB24_RS12095	2451504..2452715	+	1212	WP_001191921.1	multidrug effflux MFS transporter	-
HLB24_RS12100	2452838..2453311	-	474	WP_000456483.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T156203 WP_000482647.1 NZ_CP053183:c2448673-2448566 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T156203 NZ_CP068972:326977-327345 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT156203 NZ_CP053183:2448489-2448549 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin