Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2423218..2423735 Replicon chromosome
Accession NZ_CP053183
Organism Staphylococcus aureus strain Guangzhou-SAU071

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag HLB24_RS11935 Protein ID WP_000113263.1
Coordinates 2423218..2423484 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag HLB24_RS11940 Protein ID WP_000584499.1
Coordinates 2423484..2423735 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB24_RS11910 2418478..2419014 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
HLB24_RS11915 2419427..2420251 - 825 WP_000594633.1 formate/nitrite transporter family protein -
HLB24_RS11920 2420455..2420637 - 183 WP_000079140.1 hypothetical protein -
HLB24_RS11925 2420724..2421191 - 468 WP_000153338.1 SRPBCC domain-containing protein -
HLB24_RS11930 2421377..2422924 - 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HLB24_RS11935 2423218..2423484 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
HLB24_RS11940 2423484..2423735 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HLB24_RS11945 2423908..2423999 - 92 Protein_2306 hypothetical protein -
HLB24_RS11950 2424006..2424605 - 600 WP_000162810.1 DsbA family protein -
HLB24_RS11955 2424624..2424986 - 363 WP_000819839.1 DUF4467 domain-containing protein -
HLB24_RS11960 2425241..2426491 + 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
HLB24_RS11965 2426588..2427319 - 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
HLB24_RS11970 2427316..2428035 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T156202 WP_000113263.1 NZ_CP053183:c2423484-2423218 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T156202 NZ_CP068830:c5078067-5077756 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT156202 WP_000584499.1 NZ_CP053183:c2423735-2423484 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT156202 NZ_CP068830:c5077755-5077465 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References