Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 2423218..2423735 | Replicon | chromosome |
Accession | NZ_CP053183 | ||
Organism | Staphylococcus aureus strain Guangzhou-SAU071 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | A0A2S6D1N9 |
Locus tag | HLB24_RS11935 | Protein ID | WP_000113263.1 |
Coordinates | 2423218..2423484 (-) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | T1YB60 |
Locus tag | HLB24_RS11940 | Protein ID | WP_000584499.1 |
Coordinates | 2423484..2423735 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HLB24_RS11910 | 2418478..2419014 | - | 537 | WP_000185901.1 | GNAT family N-acetyltransferase | - |
HLB24_RS11915 | 2419427..2420251 | - | 825 | WP_000594633.1 | formate/nitrite transporter family protein | - |
HLB24_RS11920 | 2420455..2420637 | - | 183 | WP_000079140.1 | hypothetical protein | - |
HLB24_RS11925 | 2420724..2421191 | - | 468 | WP_000153338.1 | SRPBCC domain-containing protein | - |
HLB24_RS11930 | 2421377..2422924 | - | 1548 | WP_000727757.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
HLB24_RS11935 | 2423218..2423484 | - | 267 | WP_000113263.1 | Txe/YoeB family addiction module toxin | Toxin |
HLB24_RS11940 | 2423484..2423735 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
HLB24_RS11945 | 2423908..2423999 | - | 92 | Protein_2306 | hypothetical protein | - |
HLB24_RS11950 | 2424006..2424605 | - | 600 | WP_000162810.1 | DsbA family protein | - |
HLB24_RS11955 | 2424624..2424986 | - | 363 | WP_000819839.1 | DUF4467 domain-containing protein | - |
HLB24_RS11960 | 2425241..2426491 | + | 1251 | WP_001012236.1 | FemA/FemB family glycyltransferase FmhA | - |
HLB24_RS11965 | 2426588..2427319 | - | 732 | WP_000615464.1 | amino acid ABC transporter ATP-binding protein | - |
HLB24_RS11970 | 2427316..2428035 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.01 Da Isoelectric Point: 10.1628
>T156202 WP_000113263.1 NZ_CP053183:c2423484-2423218 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T156202 NZ_CP068830:c5078067-5077756 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT156202 WP_000584499.1 NZ_CP053183:c2423735-2423484 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT156202 NZ_CP068830:c5077755-5077465 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2S6D1N9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | T1YB60 |