Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2161760..2161977 Replicon chromosome
Accession NZ_CP053183
Organism Staphylococcus aureus strain Guangzhou-SAU071

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag HLB24_RS10595 Protein ID WP_001802298.1
Coordinates 2161873..2161977 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2161760..2161815 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB24_RS10575 2157951..2158616 - 666 WP_001024088.1 SDR family oxidoreductase -
HLB24_RS10580 2158768..2159088 + 321 WP_000139802.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
HLB24_RS10585 2159090..2160067 + 978 WP_000019732.1 CDF family zinc efflux transporter CzrB -
HLB24_RS10590 2160333..2161424 + 1092 WP_000495695.1 hypothetical protein -
- 2161760..2161815 + 56 - - Antitoxin
HLB24_RS10595 2161873..2161977 - 105 WP_001802298.1 hypothetical protein Toxin
HLB24_RS10600 2162138..2162621 - 484 Protein_2046 recombinase family protein -
HLB24_RS10605 2162664..2163800 - 1137 Protein_2047 SAP domain-containing protein -
HLB24_RS10610 2164089..2164181 + 93 WP_031844941.1 hypothetical protein -
HLB24_RS10615 2164876..2165733 - 858 WP_000370919.1 Cof-type HAD-IIB family hydrolase -
HLB24_RS10620 2165801..2166583 - 783 WP_000908190.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T156201 WP_001802298.1 NZ_CP053183:c2161977-2161873 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T156201 NZ_CP068830:c4784429-4784256 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 56 bp

>AT156201 NZ_CP053183:2161760-2161815 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References