Detailed information of TA system TA156200

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2161714..2161977
• Replicon: chromosome
• Accession: NZ_CP053183
• Organism: Staphylococcus aureus strain Guangzhou-SAU071

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HLB24_RS10595
• Protein ID: WP_001802298.1
• Coordinates: 2161873..2161977 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2161714..2161878 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB24_RS10575	2157951..2158616	-	666	WP_001024088.1	SDR family oxidoreductase	-
HLB24_RS10580	2158768..2159088	+	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
HLB24_RS10585	2159090..2160067	+	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
HLB24_RS10590	2160333..2161424	+	1092	WP_000495695.1	hypothetical protein	-
-	2161714..2161878	+	165	-	-	Antitoxin
HLB24_RS10595	2161873..2161977	-	105	WP_001802298.1	hypothetical protein	Toxin
HLB24_RS10600	2162138..2162621	-	484	Protein_2046	recombinase family protein	-
HLB24_RS10605	2162664..2163800	-	1137	Protein_2047	SAP domain-containing protein	-
HLB24_RS10610	2164089..2164181	+	93	WP_031844941.1	hypothetical protein	-
HLB24_RS10615	2164876..2165733	-	858	WP_000370919.1	Cof-type HAD-IIB family hydrolase	-
HLB24_RS10620	2165801..2166583	-	783	WP_000908190.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T156200 WP_001802298.1 NZ_CP053183:c2161977-2161873 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T156200 NZ_CP068830:4773126-4773503 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAATATTATCCTGGGTAAGCACCCGGAGGTGAAACAATGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT156200 NZ_CP053183:2161714-2161878 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin