Detailed information of TA system TA156194

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1853530..1853837
• Replicon: chromosome
• Accession: NZ_CP053183
• Organism: Staphylococcus aureus strain Guangzhou-SAU071

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: HLB24_RS08785
• Protein ID: WP_072357969.1
• Coordinates: 1853661..1853837 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1853530..1853669 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB24_RS08745	1848875..1849135	+	261	WP_001791826.1	hypothetical protein	-
HLB24_RS08750	1849188..1849538	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
HLB24_RS08755	1850219..1850668	+	450	WP_072491815.1	chemotaxis-inhibiting protein CHIPS	-
HLB24_RS08760	1850761..1851095	-	335	Protein_1721	SH3 domain-containing protein	-
HLB24_RS08765	1851746..1852237	-	492	WP_000920041.1	staphylokinase	-
HLB24_RS08770	1852428..1853183	-	756	WP_000861038.1	CHAP domain-containing protein	-
HLB24_RS08775	1853195..1853449	-	255	WP_000611512.1	phage holin	-
HLB24_RS08780	1853501..1853608	+	108	WP_031762631.1	hypothetical protein	-
-	1853530..1853669	+	140	NuclAT_0	-	Antitoxin
-	1853530..1853669	+	140	NuclAT_0	-	Antitoxin
-	1853530..1853669	+	140	NuclAT_0	-	Antitoxin
-	1853530..1853669	+	140	NuclAT_0	-	Antitoxin
HLB24_RS08785	1853661..1853837	-	177	WP_072357969.1	putative holin-like toxin	Toxin
HLB24_RS08790	1853980..1854354	-	375	WP_000340977.1	hypothetical protein	-
HLB24_RS08795	1854410..1854697	-	288	WP_001262620.1	hypothetical protein	-
HLB24_RS08800	1854743..1854895	-	153	WP_001000058.1	hypothetical protein	-
HLB24_RS08805	1854888..1858670	-	3783	WP_166520628.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T156194 WP_072357969.1 NZ_CP053183:c1853837-1853661 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T156194 NZ_CP068830:c4065060-4064140 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCCGGCAGGTCAAACTGTTGATGGCCGCTCTGCCGTATGTGGCGAAGGAGTCCTGTTT
CGCGTTGAAAGGCGGCACCGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATTGATCTGGCGTACA
AGAGCTTTGCGGATCGCGATACTGATTTGGCGGCTATCAACGACGCTTTGAAGAGGATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATCTGCGCTGCGCTTGATCGTCAGCAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGCCCCATCGCCGAGTTGCTGGCTCCAAACTGGGATACAGAGCGGATCGCCACGTTGTACGCGC
AGGAATTTTCAGGGATGACGCAACAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGGTGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTTCTGGCGTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT156194 NZ_CP053183:1853530-1853669 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin