Detailed information of TA system TA156174

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2632596..2632858
• Replicon: chromosome
• Accession: NZ_CP053181
• Organism: Enterococcus faecalis strain FMAMOB6

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: HLJ13_RS12825
• Protein ID: WP_002392696.1
• Coordinates: 2632715..2632858 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2632596..2632741 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLJ13_RS12810	2628011..2630755	+	2745	WP_025189669.1	glycosyl hydrolase family 65 protein	-
HLJ13_RS12815	2630770..2631420	+	651	WP_002398182.1	beta-phosphoglucomutase	-
HLJ13_RS12820	2631882..2632475	+	594	WP_002398183.1	PBECR4 domain-containing protein	-
-	2632596..2632741	+	146	-	-	Antitoxin
HLJ13_RS12825	2632715..2632858	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
HLJ13_RS12830	2633090..2634061	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
HLJ13_RS12835	2634236..2634673	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
HLJ13_RS12840	2634806..2635360	-	555	WP_002354869.1	Maf family protein	-
HLJ13_RS12845	2635385..2637517	-	2133	WP_010716772.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T156174 WP_002392696.1 NZ_CP053181:c2632858-2632715 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T156174 NZ_CP068830:c72958-72581 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCATTTGTCCCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin

Nucleotide

• Length: 146 bp

>AT156174 NZ_CP053181:2632596-2632741 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin