Detailed information of TA system TA156168

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2563803..2564026
• Replicon: chromosome
• Accession: NZ_CP053181
• Organism: Enterococcus faecalis strain FMAMOB6

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: HLJ13_RS12490
• Protein ID: WP_075551663.1
• Coordinates: 2563925..2564026 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2563803..2563980 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLJ13_RS12465	2559450..2560403	-	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-
HLJ13_RS12470	2560442..2561197	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
HLJ13_RS12475	2561194..2562159	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
HLJ13_RS12480	2562156..2563103	-	948	WP_010716775.1	iron chelate uptake ABC transporter family permease subunit	-
HLJ13_RS12485	2563288..2563740	+	453	WP_002354958.1	YueI family protein	-
-	2563803..2563980	+	178	-	-	Antitoxin
HLJ13_RS12490	2563925..2564026	-	102	WP_075551663.1	putative holin-like toxin	Toxin
HLJ13_RS12495	2564358..2564459	-	102	WP_075551663.1	putative holin-like toxin	-
HLJ13_RS12500	2564649..2566919	-	2271	WP_002398160.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
HLJ13_RS12505	2567090..2567590	+	501	WP_002365352.1	cysteine hydrolase family protein	-
HLJ13_RS12510	2567893..2568789	+	897	WP_002354953.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T156168 WP_075551663.1 NZ_CP053181:c2564026-2563925 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T156168 NZ_CP068829:c4349950-4349741 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin

Nucleotide

• Length: 178 bp

>AT156168 NZ_CP053181:2563803-2563980 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Structures

Antitoxin