Detailed information of TA system TA156125

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): yonT-SR6/-
• Location: 2332102..2332319
• Replicon: chromosome
• Accession: NZ_CP053102
• Organism: Bacillus subtilis subsp. subtilis str. 168

Toxin (Protein)

• Gene name: yonT
• Uniprot ID: O31941
• Locus tag: HIR77_RS12150
• Protein ID: WP_009967515.1
• Coordinates: 2332143..2332319 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SR6
Locus tag	-
Coordinates	2332102..2332202 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HIR77_RS12120	2327331..2327558	-	228	WP_004399298.1	helix-turn-helix transcriptional regulator	-
HIR77_RS12125	2327819..2329135	-	1317	WP_004399369.1	hypothetical protein	-
HIR77_RS12130	2329492..2329998	-	507	WP_004399486.1	hypothetical protein	-
HIR77_RS12135	2330326..2331558	-	1233	WP_004399445.1	hypothetical protein	-
HIR77_RS12140	2331640..2331828	-	189	WP_004399547.1	hypothetical protein	-
HIR77_RS12145	2331873..2332124	-	252	WP_010886546.1	hypothetical protein	-
-	2332102..2332202	+	101	-	-	Antitoxin
HIR77_RS12150	2332143..2332319	-	177	WP_009967515.1	hypothetical protein	Toxin
-	2332260..2332360	+	101	NuclAT_3	-	-
-	2332260..2332360	+	101	NuclAT_3	-	-
-	2332260..2332360	+	101	NuclAT_3	-	-
-	2332260..2332360	+	101	NuclAT_3	-	-
HIR77_RS12155	2332694..2333305	-	612	WP_009967516.1	lipoprotein	-
HIR77_RS12160	2333420..2333746	-	327	WP_009967517.1	helix-turn-helix domain-containing protein	-
HIR77_RS12165	2334699..2334893	+	195	WP_004399291.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2141170..2398767	257597

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6882.45 Da
• Isoelectric Point: 12.8833

>T156125 WP_009967515.1 NZ_CP053102:c2332319-2332143 [Bacillus subtilis subsp. subtilis str. 168]
VLEKMGIVVAFLISLTVLTINSLTIVEKVRNLKNGTSKKKKRIRKRLRPKRQRQRIRR

Nucleotide

• Length: 177 bp

>T156125 NZ_CP068827:c5277542-5277435 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 101 bp

>AT156125 NZ_CP053102:2332102-2332202 [Bacillus subtilis subsp. subtilis str. 168]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Structures

Toxin

• AlphaFold DB: O31941

Antitoxin