Detailed information of TA system TA156118

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): bsrG-as-bsrG/-
• Location: 2260636..2260933
• Replicon: chromosome
• Accession: NZ_CP053102
• Organism: Bacillus subtilis subsp. subtilis str. 168

Toxin (Protein)

• Gene name: bsrG
• Uniprot ID: L8EAY0
• Locus tag: HIR77_RS11560
• Protein ID: WP_009967548.1
• Coordinates: 2260636..2260752 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	as-bsrG
Locus tag	-
Coordinates	2260747..2260933 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HIR77_RS11520	2255751..2256143	+	393	WP_017696898.1	hypothetical protein	-
HIR77_RS11525	2256165..2256416	+	252	WP_061891069.1	phage holin	-
HIR77_RS11530	2256544..2257680	+	1137	WP_017696900.1	tetratricopeptide repeat protein	-
HIR77_RS11535	2257670..2257846	+	177	WP_017696901.1	hypothetical protein	-
HIR77_RS11540	2257888..2259138	-	1251	WP_170272657.1	UV damage repair protein UvrX	-
HIR77_RS11545	2259131..2259463	-	333	WP_109962767.1	YolD-like family protein	-
HIR77_RS11550	2259637..2259972	+	336	WP_041054825.1	hypothetical protein	-
HIR77_RS11555	2260016..2260375	-	360	WP_041338710.1	hypothetical protein	-
HIR77_RS11560	2260636..2260752	+	117	WP_009967548.1	type I toxin-antitoxin system toxin BsrG	Toxin
-	2260747..2260933	-	187	NuclAT_2	-	Antitoxin
-	2260747..2260933	-	187	NuclAT_2	-	Antitoxin
-	2260747..2260933	-	187	NuclAT_2	-	Antitoxin
-	2260747..2260933	-	187	NuclAT_2	-	Antitoxin
HIR77_RS11565	2260979..2261437	-	459	WP_086352808.1	SMI1/KNR4 family protein	-
HIR77_RS11570	2261542..2262105	-	564	WP_086352807.1	SMI1/KNR4 family protein	-
HIR77_RS11575	2262107..2263861	-	1755	WP_170272658.1	HNH endonuclease	-
HIR77_RS11580	2264276..2265160	+	885	WP_170272659.1	endonuclease YokF	-
HIR77_RS11585	2265284..2265817	-	534	WP_170272660.1	N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2141170..2398767	257597

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-38)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4336.39 Da
• Isoelectric Point: 10.1022

>T156118 WP_009967548.1 NZ_CP053102:2260636-2260752 [Bacillus subtilis subsp. subtilis str. 168]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Nucleotide

• Length: 117 bp

>T156118 NZ_CP068827:3774354-3774563 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin

Nucleotide

• Length: 187 bp

>AT156118 NZ_CP053102:c2260933-2260747 [Bacillus subtilis subsp. subtilis str. 168]
AATGATACAAATAATTATTTATTGCATTTTGATTTGTGGAAATGCATAAAATAAAAAAAGACCTGGGGTGCGCTAACACC
CACTGGTCATTGTTTGTACAAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGG
TGTCCAAACTCAAGGGAAGGTCTATTT

Structures

Toxin

• AlphaFold DB: A0A7Z7EVU9

Antitoxin