156109

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2541345..2541868 Replicon chromosome
Accession NZ_CP053101
Organism Staphylococcus aureus strain EDCC5398

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag HLB22_RS12650 Protein ID WP_000074048.1
Coordinates 2541345..2541611 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag HLB22_RS12655 Protein ID WP_000587616.1
Coordinates 2541611..2541868 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB22_RS12630 2536556..2537743 - 1188 WP_000026196.1 MFS transporter -
HLB22_RS12635 2538137..2538913 - 777 WP_000072155.1 iron export ABC transporter permease subunit FetB -
HLB22_RS12640 2538906..2539568 - 663 WP_000923509.1 ATP-binding cassette domain-containing protein -
HLB22_RS12645 2539914..2540990 - 1077 WP_001076688.1 M42 family metallopeptidase -
HLB22_RS12650 2541345..2541611 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
HLB22_RS12655 2541611..2541868 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HLB22_RS12660 2542227..2542682 + 456 WP_000732088.1 DUF1307 domain-containing protein -
HLB22_RS12665 2542850..2544427 - 1578 WP_000143486.1 FMN-binding glutamate synthase family protein -
HLB22_RS12670 2544622..2545371 + 750 WP_000072439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2537096..2588631 51535


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T156109 WP_000074048.1 NZ_CP053101:c2541611-2541345 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T156109 NZ_CP068827:c2621057-2620950 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT156109 WP_000587616.1 NZ_CP053101:c2541868-2541611 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT156109 NZ_CP068827:2621115-2621169 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References