Detailed information of TA system TA156106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2483338..2483855
• Replicon: chromosome
• Accession: NZ_CP053101
• Organism: Staphylococcus aureus strain EDCC5398

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HLB22_RS12370
• Protein ID: WP_000113261.1
• Coordinates: 2483338..2483604 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: HLB22_RS12375
• Protein ID: WP_000584499.1
• Coordinates: 2483604..2483855 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB22_RS12345	2478775..2479311	-	537	WP_000169319.1	GNAT family N-acetyltransferase	-
HLB22_RS12350	2479545..2480369	-	825	WP_000594637.1	formate/nitrite transporter family protein	-
HLB22_RS12355	2480572..2480754	-	183	WP_000250735.1	hypothetical protein	-
HLB22_RS12360	2480841..2481308	-	468	WP_000153345.1	SRPBCC domain-containing protein	-
HLB22_RS12365	2481494..2483044	-	1551	WP_000727760.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
HLB22_RS12370	2483338..2483604	-	267	WP_000113261.1	Txe/YoeB family addiction module toxin	Toxin
HLB22_RS12375	2483604..2483855	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HLB22_RS12380	2484018..2484119	-	102	Protein_2393	hypothetical protein	-
HLB22_RS12385	2484126..2484725	-	600	WP_000162810.1	DsbA family protein	-
HLB22_RS12390	2484744..2485106	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
HLB22_RS12395	2485361..2486611	+	1251	WP_001012231.1	FemA/FemB family glycyltransferase FmhA	-
HLB22_RS12400	2486696..2487427	-	732	WP_000615455.1	amino acid ABC transporter ATP-binding protein	-
HLB22_RS12405	2487424..2488143	-	720	WP_000479573.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10452.02 Da
• Isoelectric Point: 10.0373

>T156106 WP_000113261.1 NZ_CP053101:c2483604-2483338 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T156106 NZ_CP068827:2203429-2203893 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT156106 WP_000584499.1 NZ_CP053101:c2483855-2483604 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT156106 NZ_CP068827:2203094-2203429 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7BWF
• PDB: 6L8E
• AlphaFold DB: T1YB60