Detailed information of TA system TA156101

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF2/-
• Location: 2046451..2046750
• Replicon: chromosome
• Accession: NZ_CP053101
• Organism: Staphylococcus aureus strain EDCC5398

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: HLB22_RS10030
• Protein ID: WP_011447039.1
• Coordinates: 2046574..2046750 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2046451..2046506 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB22_RS09990	2041782..2042042	+	261	WP_001791826.1	hypothetical protein	-
HLB22_RS09995	2042095..2042445	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
HLB22_RS10000	2043130..2043579	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
HLB22_RS10005	2043674..2044009	-	336	Protein_1932	SH3 domain-containing protein	-
HLB22_RS10010	2044659..2045150	-	492	WP_000919349.1	staphylokinase	-
HLB22_RS10015	2045341..2046096	-	756	WP_000861039.1	CHAP domain-containing protein	-
HLB22_RS10020	2046108..2046362	-	255	WP_000611512.1	phage holin	-
HLB22_RS10025	2046414..2046521	+	108	WP_001791821.1	hypothetical protein	-
-	2046443..2046582	+	140	NuclAT_1	-	-
-	2046443..2046582	+	140	NuclAT_1	-	-
-	2046443..2046582	+	140	NuclAT_1	-	-
-	2046443..2046582	+	140	NuclAT_1	-	-
-	2046451..2046506	+	56	-	-	Antitoxin
HLB22_RS10030	2046574..2046750	-	177	WP_011447039.1	putative holin-like toxin	Toxin
HLB22_RS10035	2046900..2047196	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
HLB22_RS10040	2047254..2047541	-	288	WP_001040261.1	hypothetical protein	-
HLB22_RS10045	2047588..2047740	-	153	WP_001153681.1	hypothetical protein	-
HLB22_RS10050	2047730..2051515	-	3786	WP_000582168.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2042095..2097324	55229

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T156101 WP_011447039.1 NZ_CP053101:c2046750-2046574 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T156101 NZ_CP068827:c908210-907959 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT156101 NZ_CP053101:2046451-2046506 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin