Detailed information of TA system TA156097

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1893360..1893540
• Replicon: chromosome
• Accession: NZ_CP053101
• Organism: Staphylococcus aureus strain EDCC5398

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: HLB22_RS09070
• Protein ID: WP_001801861.1
• Coordinates: 1893360..1893455 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1893483..1893540 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB22_RS09025	1889141..1889767	+	627	WP_000669029.1	hypothetical protein	-
HLB22_RS09030	1889808..1890149	+	342	WP_000627536.1	DUF3969 family protein	-
HLB22_RS09035	1890250..1890822	+	573	WP_000414208.1	hypothetical protein	-
HLB22_RS09040	1891019..1891588	-	570	WP_000864144.1	ImmA/IrrE family metallo-endopeptidase	-
HLB22_RS09045	1891774..1891959	-	186	WP_000809864.1	hypothetical protein	-
HLB22_RS09050	1891961..1892137	-	177	WP_000375476.1	hypothetical protein	-
HLB22_RS09055	1892148..1892531	-	384	WP_000070809.1	hypothetical protein	-
HLB22_RS09060	1892713..1892937	-	225	WP_001805677.1	IS3 family transposase	-
HLB22_RS09065	1893111..1893215	-	105	WP_001670380.1	transposase	-
HLB22_RS09070	1893360..1893455	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1893483..1893540	-	58	-	-	Antitoxin
HLB22_RS09075	1893578..1893679	+	102	WP_001791232.1	hypothetical protein	-
HLB22_RS09080	1893657..1893829	-	173	Protein_1786	transposase	-
HLB22_RS09085	1894023..1894400	-	378	WP_001036002.1	DUF1433 domain-containing protein	-
HLB22_RS09090	1894606..1895046	-	441	WP_000759947.1	DUF1433 domain-containing protein	-
HLB22_RS09095	1895091..1896704	+	1614	WP_000926708.1	lipase	-
HLB22_RS09100	1896719..1897018	+	300	WP_000095392.1	WXG100 family type VII secretion target	-
HLB22_RS09105	1897335..1898516	-	1182	WP_000162901.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk	1866212..1909771	43559

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T156097 WP_001801861.1 NZ_CP053101:1893360-1893455 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T156097 NZ_CP068827:c341880-340558 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
TGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGGAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGGTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGCCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT156097 NZ_CP053101:c1893540-1893483 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin