Detailed information of TA system TA156094

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1560661..1561240
• Replicon: chromosome
• Accession: NZ_CP053101
• Organism: Staphylococcus aureus strain EDCC5398

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: HLB22_RS07390
• Protein ID: WP_001025401.1
• Coordinates: 1560995..1561240 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1560661..1561026 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB22_RS07350	1557407..1557961	-	555	WP_000647288.1	DUF2815 family protein	-
HLB22_RS07355	1557987..1559153	-	1167	WP_000762534.1	DUF2800 domain-containing protein	-
HLB22_RS07360	1559150..1559512	-	363	WP_000985986.1	hypothetical protein	-
HLB22_RS07365	1559527..1559850	-	324	WP_000175000.1	hypothetical protein	-
HLB22_RS07370	1559929..1560090	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
HLB22_RS07375	1560103..1560366	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
HLB22_RS07380	1560391..1560606	-	216	WP_001097552.1	hypothetical protein	-
HLB22_RS07385	1560661..1561026	+	366	WP_001128433.1	hypothetical protein	Antitoxin
HLB22_RS07390	1560995..1561240	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
HLB22_RS07395	1561307..1561687	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
HLB22_RS07400	1561674..1561871	-	198	WP_001148860.1	hypothetical protein	-
HLB22_RS07405	1561941..1562153	+	213	WP_000362644.1	hypothetical protein	-
HLB22_RS07410	1562194..1562343	-	150	WP_000771849.1	hypothetical protein	-
HLB22_RS07415	1562358..1562801	-	444	WP_000435357.1	hypothetical protein	-
HLB22_RS07420	1562849..1563061	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
HLB22_RS07425	1563213..1563944	+	732	WP_000511090.1	XRE family transcriptional regulator	-
HLB22_RS07430	1564015..1564197	+	183	WP_000705240.1	hypothetical protein	-
HLB22_RS07435	1564234..1564380	+	147	WP_001795334.1	hypothetical protein	-
HLB22_RS07440	1564377..1564991	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1513632..1580524	66892

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T156094 WP_001025401.1 NZ_CP053101:c1561240-1560995 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T156094 NZ_CP068826:c5053614-5053303 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT156094 NZ_CP053101:1560661-1561026 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin