Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | txpA-SprF3/- |
Location | 1524297..1524596 | Replicon | chromosome |
Accession | NZ_CP053101 | ||
Organism | Staphylococcus aureus strain EDCC5398 |
Toxin (Protein)
Gene name | txpA | Uniprot ID | Q2FWU9 |
Locus tag | HLB22_RS07140 | Protein ID | WP_011447039.1 |
Coordinates | 1524420..1524596 (-) | Length | 59 a.a. |
Antitoxin (RNA)
Gene name | SprF3 | ||
Locus tag | - | ||
Coordinates | 1524297..1524352 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HLB22_RS07110 | 1519531..1519746 | - | 216 | WP_170267452.1 | hypothetical protein | - |
HLB22_RS07115 | 1519925..1520935 | - | 1011 | WP_000777019.1 | restriction endonuclease subunit S | - |
HLB22_RS07120 | 1520922..1522826 | - | 1905 | WP_001003363.1 | N-6 DNA methylase | - |
HLB22_RS07125 | 1523187..1523942 | - | 756 | WP_000861038.1 | CHAP domain-containing protein | - |
HLB22_RS07130 | 1523954..1524208 | - | 255 | WP_000611512.1 | phage holin | - |
HLB22_RS07135 | 1524260..1524367 | + | 108 | WP_001791821.1 | hypothetical protein | - |
- | 1524289..1524428 | + | 140 | NuclAT_0 | - | - |
- | 1524289..1524428 | + | 140 | NuclAT_0 | - | - |
- | 1524289..1524428 | + | 140 | NuclAT_0 | - | - |
- | 1524289..1524428 | + | 140 | NuclAT_0 | - | - |
- | 1524297..1524352 | + | 56 | - | - | Antitoxin |
HLB22_RS07140 | 1524420..1524596 | - | 177 | WP_011447039.1 | putative holin-like toxin | Toxin |
HLB22_RS07145 | 1524749..1525048 | - | 300 | WP_000466784.1 | DUF2951 domain-containing protein | - |
HLB22_RS07150 | 1525094..1525258 | - | 165 | WP_000916020.1 | XkdX family protein | - |
HLB22_RS07155 | 1525251..1525640 | - | 390 | WP_001166596.1 | DUF2977 domain-containing protein | - |
HLB22_RS07160 | 1525640..1527106 | - | 1467 | WP_000067127.1 | BppU family phage baseplate upper protein | - |
HLB22_RS07165 | 1527106..1529016 | - | 1911 | WP_000429558.1 | minor structural protein | - |
HLB22_RS07170 | 1529032..1529322 | - | 291 | WP_000179858.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1513632..1580524 | 66892 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T156092 WP_011447039.1 NZ_CP053101:c1524596-1524420 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T156092 NZ_CP068826:4744910-4745287 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 56 bp
>AT156092 NZ_CP053101:1524297-1524352 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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