Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 1524289..1524596 Replicon chromosome
Accession NZ_CP053101
Organism Staphylococcus aureus strain EDCC5398

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag HLB22_RS07140 Protein ID WP_011447039.1
Coordinates 1524420..1524596 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 1524289..1524428 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB22_RS07110 1519531..1519746 - 216 WP_170267452.1 hypothetical protein -
HLB22_RS07115 1519925..1520935 - 1011 WP_000777019.1 restriction endonuclease subunit S -
HLB22_RS07120 1520922..1522826 - 1905 WP_001003363.1 N-6 DNA methylase -
HLB22_RS07125 1523187..1523942 - 756 WP_000861038.1 CHAP domain-containing protein -
HLB22_RS07130 1523954..1524208 - 255 WP_000611512.1 phage holin -
HLB22_RS07135 1524260..1524367 + 108 WP_001791821.1 hypothetical protein -
- 1524289..1524428 + 140 NuclAT_0 - Antitoxin
- 1524289..1524428 + 140 NuclAT_0 - Antitoxin
- 1524289..1524428 + 140 NuclAT_0 - Antitoxin
- 1524289..1524428 + 140 NuclAT_0 - Antitoxin
HLB22_RS07140 1524420..1524596 - 177 WP_011447039.1 putative holin-like toxin Toxin
HLB22_RS07145 1524749..1525048 - 300 WP_000466784.1 DUF2951 domain-containing protein -
HLB22_RS07150 1525094..1525258 - 165 WP_000916020.1 XkdX family protein -
HLB22_RS07155 1525251..1525640 - 390 WP_001166596.1 DUF2977 domain-containing protein -
HLB22_RS07160 1525640..1527106 - 1467 WP_000067127.1 BppU family phage baseplate upper protein -
HLB22_RS07165 1527106..1529016 - 1911 WP_000429558.1 minor structural protein -
HLB22_RS07170 1529032..1529322 - 291 WP_000179858.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1513632..1580524 66892


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(30-58)


Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T156091 WP_011447039.1 NZ_CP053101:c1524596-1524420 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T156091 NZ_CP068826:c4565731-4565381 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 140 bp

>AT156091 NZ_CP053101:1524289-1524428 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7NS1


Antitoxin

Download structure file

References