Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1311878..1312442 Replicon chromosome
Accession NZ_CP053093
Organism Lacticaseibacillus paracasei strain CLP-Y5

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag HLG73_RS06680 Protein ID WP_273634747.1
Coordinates 1312140..1312442 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag HLG73_RS06675 Protein ID WP_003570051.1
Coordinates 1311878..1312147 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLG73_RS06645 (HLG73_06740) 1306882..1307769 - 888 WP_003570041.1 ABC transporter ATP-binding protein -
HLG73_RS06650 (HLG73_06745) 1307967..1309193 - 1227 WP_273634743.1 hypothetical protein -
HLG73_RS06655 (HLG73_06750) 1309391..1309795 + 405 WP_273634744.1 MerR family transcriptional regulator -
HLG73_RS06660 (HLG73_06755) 1309788..1310114 + 327 WP_012491509.1 YrdB family protein -
HLG73_RS06665 (HLG73_06760) 1310177..1310806 + 630 WP_273634745.1 DUF2399 domain-containing protein -
HLG73_RS06670 (HLG73_06765) 1310851..1311504 + 654 WP_273634746.1 GNAT family N-acetyltransferase -
HLG73_RS06675 (HLG73_06770) 1311878..1312147 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HLG73_RS06680 (HLG73_06775) 1312140..1312442 + 303 WP_273634747.1 type II toxin-antitoxin system YafQ family toxin Toxin
HLG73_RS06685 (HLG73_06780) 1312781..1312924 + 144 WP_162259784.1 hypothetical protein -
HLG73_RS06690 (HLG73_06785) 1313042..1313734 + 693 WP_273634748.1 hypothetical protein -
HLG73_RS06695 (HLG73_06790) 1313970..1316147 + 2178 WP_273634749.1 Tex family protein -
HLG73_RS06700 (HLG73_06795) 1316533..1317243 + 711 WP_273634750.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11509.39 Da        Isoelectric Point: 10.1975

>T156081 WP_273634747.1 NZ_CP053093:1312140-1312442 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIK
QQDLILTLVRTGSHHNLLVK

Download         Length: 303 bp

>T156081 NZ_CP068826:2956168-2956275 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT156081 WP_003570051.1 NZ_CP053093:1311878-1312147 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT156081 NZ_CP068826:c2956121-2956055 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References