Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2962782..2963430 Replicon chromosome
Accession NZ_CP053092
Organism Mycobacterium tuberculosis strain 4860

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag HGO90_RS13910 Protein ID WP_003899414.1
Coordinates 2962782..2963105 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag HGO90_RS13915 Protein ID WP_003899415.1
Coordinates 2963185..2963430 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO90_RS13880 2958105..2959103 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
HGO90_RS13885 2959117..2959581 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
HGO90_RS13890 2959569..2959820 + 252 WP_003908028.1 hypothetical protein -
HGO90_RS13895 2959991..2961430 - 1440 WP_003899411.1 phage major capsid protein -
HGO90_RS13900 2961438..2961971 - 534 WP_003899412.1 HK97 family phage prohead protease -
HGO90_RS13905 2962124..2962615 - 492 WP_003900541.1 phage terminase small subunit P27 family -
HGO90_RS13910 2962782..2963105 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
HGO90_RS13915 2963185..2963430 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
HGO90_RS13920 2963427..2964854 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
HGO90_RS13925 2964856..2965248 - 393 WP_003899417.1 DUF2742 domain-containing protein -
HGO90_RS13930 2965245..2965505 - 261 WP_014585547.1 helix-turn-helix domain-containing protein -
HGO90_RS13935 2965522..2965884 - 363 WP_003900543.1 hypothetical protein -
HGO90_RS13940 2965887..2967014 - 1128 WP_003899420.1 site-specific integrase -
HGO90_RS13945 2967159..2967386 - 228 WP_003899421.1 hypothetical protein -
HGO90_RS13950 2967383..2967772 - 390 WP_003899422.1 hypothetical protein -
HGO90_RS13955 2967678..2967950 + 273 WP_003900544.1 hypothetical protein -
HGO90_RS13960 2968049..2968282 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2958105..2967014 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T156067 WP_003899414.1 NZ_CP053092:c2963105-2962782 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T156067 NZ_CP068825:c4705642-4705457 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT156067 WP_003899415.1 NZ_CP053092:c2963430-2963185 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT156067 NZ_CP068825:c4705440-4705030 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References