Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2182892..2183760 | Replicon | chromosome |
| Accession | NZ_CP053092 | ||
| Organism | Mycobacterium tuberculosis strain 4860 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | HGO90_RS10140 | Protein ID | WP_010886136.1 |
| Coordinates | 2182892..2183269 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | HGO90_RS10145 | Protein ID | WP_003409886.1 |
| Coordinates | 2183311..2183760 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HGO90_RS10090 | 2178681..2179133 | - | 453 | WP_003899095.1 | lipoprotein | - |
| HGO90_RS10095 | 2179197..2179598 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| HGO90_RS10100 | 2179591..2179773 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| HGO90_RS10105 | 2179887..2180237 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| HGO90_RS10110 | 2180248..2181150 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| HGO90_RS10115 | 2181171..2181362 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| HGO90_RS10120 | 2181363..2181659 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| HGO90_RS10125 | 2181899..2182114 | + | 216 | WP_003409878.1 | antitoxin | - |
| HGO90_RS10130 | 2182111..2182422 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| HGO90_RS10135 | 2182396..2182917 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| HGO90_RS10140 | 2182892..2183269 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| HGO90_RS10145 | 2183311..2183760 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| HGO90_RS10150 | 2183757..2184302 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| HGO90_RS10155 | 2184191..2184805 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| HGO90_RS10160 | 2184854..2185150 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HGO90_RS10165 | 2185147..2185398 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| HGO90_RS10170 | 2185385..2185879 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| HGO90_RS10175 | 2186039..2186446 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| HGO90_RS10180 | 2186450..2186722 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HGO90_RS10185 | 2186755..2187975 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T156051 WP_010886136.1 NZ_CP053092:2182892-2183269 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T156051 NZ_CP068825:c546866-546525 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT156051 WP_003409886.1 NZ_CP053092:2183311-2183760 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT156051 NZ_CP068825:546861-546937 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|