Detailed information of TA system TA155988

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4464067..4464479
• Replicon: chromosome
• Accession: NZ_CP053080
• Organism: Escherichia coli strain HB37

Toxin (Protein)

• Gene name: symE
• Uniprot ID: S1NWQ7
• Locus tag: HKW69_RS21515
• Protein ID: WP_000132614.1
• Coordinates: 4464138..4464479 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4464067..4464143 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKW69_RS21505	4460742..4462211	+	1470	WP_001540814.1	type I restriction-modification system subunit M	-
HKW69_RS21510	4462211..4463917	+	1707	WP_001100194.1	restriction endonuclease subunit S	-
-	4464067..4464143	-	77	NuclAT_6	-	Antitoxin
-	4464067..4464143	-	77	NuclAT_6	-	Antitoxin
-	4464067..4464143	-	77	NuclAT_6	-	Antitoxin
-	4464067..4464143	-	77	NuclAT_6	-	Antitoxin
-	4464067..4464143	-	77	NuclAT_7	-	Antitoxin
-	4464067..4464143	-	77	NuclAT_7	-	Antitoxin
-	4464067..4464143	-	77	NuclAT_7	-	Antitoxin
-	4464067..4464143	-	77	NuclAT_7	-	Antitoxin
HKW69_RS21515	4464138..4464479	+	342	WP_000132614.1	endoribonuclease SymE	Toxin
HKW69_RS21520	4464526..4466619	-	2094	WP_000648237.1	DUF262 domain-containing protein	-
HKW69_RS21525	4466717..4466797	-	81	WP_020233658.1	hypothetical protein	-
HKW69_RS21530	4467025..4467945	-	921	WP_000181195.1	Rpn family recombination-promoting nuclease/putative transposase	-
HKW69_RS21535	4468130..4469410	+	1281	WP_001298033.1	DUF445 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	cheD	4447947..4466682	18735

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12266.07 Da
• Isoelectric Point: 8.4982

>T155988 WP_000132614.1 NZ_CP053080:4464138-4464479 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T155988 NZ_CP068822:c3870305-3869928 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCTGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTGCGTACCGACCAGCCGGGATTC
AGCCCCTGTACCCGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT155988 NZ_CP053080:c4464143-4464067 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: S1NWQ7

Antitoxin