155936

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 3654..4258 Replicon plasmid pSA01-03
Accession NZ_CP053077
Organism Staphylococcus aureus strain SA01

Toxin (Protein)


Gene name pemK Uniprot ID L7PFJ6
Locus tag HK402_RS14655 Protein ID WP_001022435.1
Coordinates 3654..3992 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID L7PH55
Locus tag HK402_RS14660 Protein ID WP_001129937.1
Coordinates 3989..4258 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK402_RS14635 738..971 + 234 WP_001002995.1 hypothetical protein -
HK402_RS14640 981..1391 + 411 WP_000872163.1 hypothetical protein -
HK402_RS14645 1543..2217 - 675 WP_001106066.1 IS6 family transposase -
HK402_RS14650 2796..3479 - 684 WP_000277644.1 CPBP family intramembrane metalloprotease -
HK402_RS14655 3654..3992 - 339 WP_001022435.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HK402_RS14660 3989..4258 - 270 WP_001129937.1 hypothetical protein Antitoxin
HK402_RS14665 4829..5638 + 810 WP_170172431.1 alpha/beta hydrolase -
HK402_RS14670 5751..6482 + 732 WP_000753929.1 CPBP family intramembrane metalloprotease -
HK402_RS14675 6786..7154 - 369 WP_041203784.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - - 1..17257 17257
- flank IS/Tn - - 1543..2217 674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13001.20 Da        Isoelectric Point: 10.1988

>T155936 WP_001022435.1 NZ_CP053077:c3992-3654 [Staphylococcus aureus]
MNIKQFDILYIDLNPTRGREKHNVRPCLVINNQMSIDGTNFVWVLPITTRGLRYPTDIQLKTKKGLVSGVIDTVQIRALD
LKARQYNYKDELQDNLKNDILKAIKTYLKPTL

Download         Length: 339 bp

>T155936 NZ_CP068820:c3992653-3992189 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10185.65 Da        Isoelectric Point: 10.1641

>AT155936 WP_001129937.1 NZ_CP053077:c4258-3989 [Staphylococcus aureus]
MAKSLKDLNKTSERVFKNGNSKAISLSKKTIRLANFDIGDTVEVQKMNGGLFITKKKESIEDRIKNFFQSGGKYTELEVD
WEERVGREI

Download         Length: 270 bp

>AT155936 NZ_CP068820:c3992988-3992653 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7EWJ
PDB 7EWI

Antitoxin

Source ID Structure
PDB 7EWJ
AlphaFold DB L7PH55

References