Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2566785..2566969 Replicon chromosome
Accession NZ_CP053075
Organism Staphylococcus aureus strain SA01

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag HK402_RS13000 Protein ID WP_000482652.1
Coordinates 2566862..2566969 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2566785..2566845 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK402_RS12985 2562240..2562407 - 168 Protein_2512 hypothetical protein -
HK402_RS12990 2562638..2564371 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
HK402_RS12995 2564396..2566159 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2566785..2566845 + 61 - - Antitoxin
HK402_RS13000 2566862..2566969 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
HK402_RS13005 2567103..2567489 - 387 WP_000779360.1 flippase GtxA -
HK402_RS13010 2567757..2568899 + 1143 WP_001176863.1 glycerate kinase -
HK402_RS13015 2568959..2569618 + 660 WP_000831298.1 membrane protein -
HK402_RS13020 2569800..2571011 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
HK402_RS13025 2571134..2571607 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T155932 WP_000482652.1 NZ_CP053075:c2566969-2566862 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T155932 NZ_CP068820:3524149-3524334 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 61 bp

>AT155932 NZ_CP053075:2566785-2566845 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References