Detailed information of TA system TA155931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2541290..2541807
• Replicon: chromosome
• Accession: NZ_CP053075
• Organism: Staphylococcus aureus strain SA01

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: HK402_RS12865
• Protein ID: WP_000113265.1
• Coordinates: 2541290..2541556 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: HK402_RS12870
• Protein ID: WP_000584499.1
• Coordinates: 2541556..2541807 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HK402_RS12835	2536718..2537254	-	537	WP_000169317.1	GNAT family N-acetyltransferase	-
HK402_RS12840	2537488..2538312	-	825	WP_000572038.1	formate/nitrite transporter family protein	-
HK402_RS12845	2538529..2538711	-	183	WP_000230292.1	hypothetical protein	-
HK402_RS12850	2538795..2539262	-	468	WP_000153347.1	SRPBCC domain-containing protein	-
HK402_RS12855	2539448..2540995	-	1548	WP_000727774.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
HK402_RS12860	2541184..2541255	-	72	Protein_2487	hypothetical protein	-
HK402_RS12865	2541290..2541556	-	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
HK402_RS12870	2541556..2541807	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HK402_RS12875	2541972..2542073	-	102	Protein_2490	hypothetical protein	-
HK402_RS12880	2542080..2542679	-	600	WP_000162810.1	DsbA family protein	-
HK402_RS12885	2542698..2543060	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
HK402_RS12890	2543315..2544565	+	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
HK402_RS12895	2544662..2545393	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
HK402_RS12900	2545390..2546109	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T155931 WP_000113265.1 NZ_CP053075:c2541556-2541290 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T155931 NZ_CP068820:c3362774-3362400 [Escherichia coli]
ATGAAAACATTACCCGATACACTCGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT155931 WP_000584499.1 NZ_CP053075:c2541807-2541556 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT155931 NZ_CP068820:c3363232-3362864 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGATATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAACGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA

Structures

Toxin

• PDB: 7BWF

Antitoxin

• AlphaFold DB: T1YB60